摘要
目的 :观察鼻咽癌诱导化疗的临床疗效及不良反应。方法 :1997年 3月～ 2 0 0 0年 10月 ,5 9例N2 N3期鼻咽癌患者放疗前采用DDP + 5 FU方案诱导化疗 1～ 2周期。方法为DDP 10 0mg m2 ,静脉推注 ,d1,5 FU 10 0 0mg m2 ,静脉推注 ,d1～d5,2 1d为 1周期。结果 :全组颈淋巴结化疗总有效率为88 1% ,CR 13 6%。完成 1周期化疗者有效率为 84 .6% ,CR 7.7% ,完成 2周期化疗者有效率为 95 % ,CR 2 5 %。两者CR率差别有显著性 (P >0 .0 5 )。结论 :DDP + 5 FU方案诱导化疗可作为晚期鼻咽癌治疗的有效手段 ,应用 2～ 3个周期较为合适。
Objective To observe the effect and adverse reactions of induction chemotherapy for nasopharyngeal carcinoma.Methods Form March 1997 to October 2000,59 patients with nasopharyngeal carcinoma in N 2N 3 stages were administered by one to two cycles induction chemotherapy of cisplatin (100 mg/m 2,continuous infusion on day 1 only)plus 5 fluorouracil (1000 mg/m 2,continuous infusion per day×5days).Results The overall response rate of the neck lesion for chemotherapy was 88.1% with 13.6% complete response (CR) rate.The response rate was 84.6% in one cycle chemotherapy and 95% in two cycles chemotherapy.The complete response (CR) rate was 7.7% in one cycle chemotherapy and 25% in two cycles chemotherapy ( P <0 05).Conclusions The induction chemotherapy of DDP+5 FU was highly effective for advanced nasopharyngeal carcinoma and two to three cycles were suitable.
出处
《肿瘤防治杂志》
2001年第5期495-496,共2页
China Journal of Cancer Prevention and Treatment
关键词
诱导化疗
鼻咽癌
治疗
nasopharyngeal neoplasms
induction chemotherapy
