摘要
目的 :研究 2型糖尿病患者骨密度的变化以及与骨钙素和胰岛功能的关系。方法 :使用定量超声骨量 (QUS)分析系统测定 71例 2型糖尿病踝中部骨超声指数 (OSI) ,根据其测定结果将 2型糖尿病患者分为骨量正常组、骨量减低组和骨质疏松组 ,并与同年龄的正常对照组相比较。同时测定 2型糖尿病患者的血清骨钙素 (BGP)、C肽、血糖、血钙、血磷及血浆硷性磷酸酶等进行组间比较。结果 :2型糖尿病患者OSI低于对照组 ,差异显著 (P <0 .0 1)。 2型糖尿病BGP和C肽值三组间相比较差异显著 (P <0 .0 1)。结论 :2型糖尿病患者骨质疏松的发生比例高于正常人。骨密度降低者BGP和C肽呈同步降低 ,说明2型糖尿病患者的骨质疏松可能与胰岛功能降低有关。血浆骨钙素测定可以作为骨质疏松的监测指标之一。早期诊断糖尿病并及时予以有效的治疗 。
Objective:To investigate the change of bone mineral density in patients with type 2 diabetes mellitus and the relationship with bone glaprotein and function of pancreas island. Methods: OSI of middle ankle in 71 patients with type 2 diabetes mellitus were measured with QUS dialysis system. These patients were divided into the group of normal bone quantity, the group of lower bone quantity and the group of osteoporosis, and were compared with the health controls. BGP, C peptide, blood glucose, blood calcium, blood phosphonium and AKP were measured and were compared within the groups. Results: OSI in patients with type 2 diabetes mellitus were significantly lower than controls ( P <0.01). BGP and C peptide in patients with type 2 diabetes mellitus were significantly different within three groups ( P <0.01). Conclusion: The osteoporosis is more often seen in type 2 diabetes mellitus than in health people. The osteoporosis in type 2 diabetes mellitus is related to lower function of pancreas island. Early diagnosis and prompt treatment can prevent the osteoporosis in type 2 diabetes mellitus.
出处
《中国临床医学》
2001年第4期405-406,共2页
Chinese Journal of Clinical Medicine
