摘要
①目的 观察奥美拉唑合用阿莫西林治疗儿童幽门螺杆菌 (Hp)阳性十二指肠溃疡的效果。 ②方法84例Hp阳性十二指肠溃疡病儿随机分为两组 ,分别给予奥美拉唑 (Ome)加阿莫西林 (Amx)和单用Ome治疗 2 8d ,定期复查胃镜和Hp感染情况。 ③结果 联合组溃疡近期愈合率与Ome组差异无显著意义 ( χ2 =0 .0 70 ,P >0 .0 5 ) ,但Hp清除率联合组显著高于Ome组 ( χ2 =4 9.90 9,P <0 .0 0 1)。联合组 0 .5 ,1.0年时溃疡累积复发率和Hp感染复发率显著低于Ome组 ( χ2 =6.2 15～ 3 5 .4 84 ,P <0 .0 5 ,0 .0 1)。④结论 奥美拉唑合用阿莫西林可提高Hp阳性十二指肠溃疡病儿Hp清除率 。
Objective\ To observe the effects of om eprazole plus amoxillin on duodenal ulcer in children with H. pylori positive. \ Methods\ 84 duodenal ulcer children with H. pylori positive were divided into two groups : omepuazole plus amoxillin group(com bined group) and omeprazole alone group(single group). Both groups were t reated for 28 days. A periodic examination with gastroscopy was done. \ Results\ There was no significant difference in terms of short term ulcer healing rate in the both groups( χ 2=0.070,P >0.05), but the eradication rate of H. pylori in combined group was signi ficantly higher than that for the single group ( χ 2=49.909,P <0. 001).The recurrence rate of ulcer in half and one year for com bined group was significantly lower than that for the single group ( χ 2=6.215-35.484,P <0.05,0.01). \ Conclusion\ Omeprazole combined amoxillin may increase the eradication rate of H.pylori and reduce short term recurrence of the ulcer.
出处
《齐鲁医学杂志》
2001年第4期289-290,共2页
Medical Journal of Qilu
