摘要
目的：探讨中国汉族人群中５－羟色胺（５－ＨＴ６）受体基因 Ｃ２６７Ｔ多态性与持续性躯体形式疼痛障碍的相互关系。方法：应用聚合酶链式反应（ＰＣＲ）－限制性片段长度多态性（ＲＦＬＰ）技术，在５１例持续性躯体形式疼痛障碍患者和６０例正常对照中观察了５－ＨＴ６受体基因多态性的分布。结果：５－ＨＴ６受体基因的Ｃ／Ｔ基因型与持续性躯体形式疼痛障碍之间存在负关联（ＯＲ＝０．４３，Ｚ＝２．０５，Ｐ＜０．０５）。结论：从整体看，５－ＨＴ６受体基因多态性与持续性躯体形式疼痛障碍的发生有关。
Objectives: To explore the inter-relationship between 5-HT6 receptor gene polymorphism and persist somatoform pain disorder in Chinese. Methods: The genetic polymorphism of 5-HT6 receptor gene was on 51 patients and 60 controls with PCR-RFLP methods. Then the association between 5-HT6 receptor gene polymorphism and patients was analyzed. Results: There was found to be negative relationship between the C/T genetype of the 5-HT5 releptor gene and somatoform pain inpa tients(OR=0.43,Z=2.05,P<0.05).Conclusion:In general,There is relationship betwe en receptor gene and somatoform pain disorder.
出处
《中国民政医学杂志》
2001年第6期323-325,共3页
Medical Journal of Chinese Civil Administration
