摘要
目的 :探讨E -cadherin、PCNA在甲状腺乳头状腺癌 (PTC)中表达的临床病理意义及其相关性。方法 :应用免疫组化SP法 ,检测 70例PTC中E -cadherin、PCNA的表达。结果 :E -cadherin的阳性表达率为 44 .3 %(31/70 ) ,PCNA标记指数为 (5 9.1± 14.6 ) % ,分别与PTC的病理分级、TNM分期淋巴结转移有关 (P <0 .0 5 ) ,而与患者性别、年龄及肿瘤大小无明显的关系 (P >0 .0 5 )。E -cadherin、PCNA的表达呈明显的负相关(P <0 .0 5 )。结论 :E -cadherin、PCNA在PTC浸润、转移过程中起重要作用 ,可作为预测PTC生物学行为的重要标志。
Objective:To investigate the clinical pathology significance and correlationship of E-cadherin and PCNA expression in the papillary thyroid carcinoma(PTC).Methods:The expression of E-cadherin and nm23 were detected by SP immunohistochemical technique in 70 Paraffin-embedded tissue specimens of PTC.Results:The positive rate of e-cadherin was 44.3%(31/70),and PCNA labeling index was 59.1±14.6.There was close relation between the expression of E-cadherin and PCNA and pathological grade, TNM stage and lymph node metastasis(P<0.05),and no difference could be found between the expression of E-cadherin and nm23 and size of tumor,sex and age of patients(P>0.05).There was obvious negative correlation between the expression of E-cadherin and PCNA(P<0.05).Conclusions:E-cadherin and PCNA might play important roles in invasion and metastasis of PTC,and might be useful markers for evaluating the biological behavior of PTC.
出处
《中国现代医学杂志》
CAS
CSCD
2001年第9期31-32,共2页
China Journal of Modern Medicine
