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肾癌血管内皮生长因子表达及肿瘤微血管密度的临床意义 被引量:1

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摘要 目的探讨血管内皮生长因子 ( VEGF)在肾癌的表达情况及肿瘤微血管密度 ( MVD)的意义。方法采用免疫组化 LSAB法对 10例肾良性肿瘤、38例肾癌中 VEGF表达进行检测 ,并对肿瘤 MVD进行测定。结果 VEGF阳性率肾癌为 6 5 .8% ,肾良性肿瘤为 2 0 %( P<0 .0 1)。 、 期肾癌为 47.8% , 、 期肾癌为 93.3% ( P<0 .0 5 )。肾癌 MVD显著高于肾良性肿瘤 ( P<0 .0 1) , 、 期肾癌MVD显著低于 、 期肾癌 ( P<0 .0 5 )。随访 2年 :VEGF及 MVD均与肾癌预后有关。结论 VEGF及 MVD在肾癌的形成及浸润发展中有重要作用 ,二者可作为判断肾癌预后的指标。
出处 《中国综合临床》 北大核心 2002年第1期80-81,共2页 Clinical Medicine of China
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