摘要
目的 了解食盐加碘 4年后石家庄市碘营养充足孕妇及所生新生儿的甲状腺功能。方法 尿碘的测定采用酸消化砷—铈接触法 ,血清 T3 、T4、FT3 和 F T4的测定采用放射免疫法 ,TSH的测定采用免疫放射法 ;新生儿脐血 TSH的测定采用 ELISA法。结果 待产母亲尿碘中位数为 2 0 3 .3 μg/ L,<10 0 μg/ L 的比率为11.1% ,母亲血清 T3 (2 .3 4± 0 .3 7) nmol/ L均在正常范围 ,T4(15 8.2 2± 2 8.19) nmol/ L在正常范围的比率为70 .8% ,超过正常上限占 2 9.2 % ,TSH (2 .43± 1.0 6) m U/ L ,<5 m U/ L的比率为 97.9% ,FT3 (2 .61± 0 .47)pmol/ L在正常低限占 17.80 % ,FT4(5 .5 0± 1.5 7) pmol/ L 在正常低限仅占 4.4% ,其余均低于正常低限。新生儿脐血 TSH中位数为 1.99m U/ L,<5 m U/ L 的比率为 90 .6%。结论 碘营养充足母亲所生新生儿 TSH>5m U/ L的比率 <10 % ,用非妊娠正常人的 FT3 、FT4正常值范围评价孕妇甲状腺功能容易造成误诊 ,各实验室应建立不同人群 (正常人、孕妇 )
Objective This study was to find out the thyroid function for iodine sufficient prepartal women and their neonates in Shijiazhuang.Methods The urinary iodine of prepartal women and their serum T 3,T 4,FT 3,FT 4 were determined by Chloric Acid digestion Thermostatic Assay and RIA,TSH determination by IRMA;Neonatal umbilical cord blood TSH was determined by ELISA.Results Median urinary iodine of prepartal women was 203.3 μg/L,the percentage that lower than 100 μg/L was 11.1%,maternal serum T 3(2.34±0.37) nmol/L were all within normal range;the percentage that T 4(158.22±28.19)nmol/L were within normal range was 70.8%,higher than normal was 29.2%;the percentage that TSH (2.43±1.06)mU/L were lower than 5 mU/L was 97.9%,FT 3(2.61±0.47)pmol/L,FT 4(5.50±1.57)pmol/L that were within lower normal range were 17.8 %,4.4% respectively,others were lower than normal range.Neonatal umbilical cord blood TSH median was 1.99 mU/L,the percentage that lower than 5 mU/L was 90.6%.Conclusions The percentage that the neonates of iodine sufficient pregnant women TSH>5 mU/L was lower than 10%,estimate the thyroid function of pregnant women with the normal range of nonpregnant FT 3 and FT 4 could cause wrong diagnosis,the normal range of thyroid hormone on different groups would be established.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2002年第1期49-51,共3页
Chinese Jouranl of Endemiology
基金
河北省卫生厅科研基金资助 ( 980 52 )
