摘要
目的 :观察硝苯地平控释片降压控制率和治疗依从性。方法 :硝苯地平控释片 ( A组 ) 4 5例、依那普利 ( B组 ) 4 2例、硝苯地平片 ( C组 ) 4 3例进行 12 m o前瞻性对比研究。结果 :A,B,C组降压谷峰值比率分别为 ( 10 1± 12 ) % ,( 65± 9) % ,( 3 6±9) % ;单药降压控制率分别为 93 .3 % ,76.2 % ,65 .1% ;治疗依从性比率分别为 86.6% ,5 4 .8% ,3 4 .9% ;A,B,C组的单药降压控制率、治疗依从性比率均与谷峰值比率呈正相关关系 ,r分别为 0 .83 ,0 .79,0 .80 ,0 .76,0 .78,0 .77。A组明显优于 B,C组 ( P<0 .0 5 - 0 .0 1)。治疗依从性差原因中 ,因无效、病情加重、不良反应、漏服药的发生率 ,A组明显少于 B,C组 ( P<0 .0 5 -0 .0 1)。仅降压费用高一项 A组更为明显。结论 :硝苯地平控释片单药降压控制率高、不良反应少、治疗依从性好 。
AIM: To compare the antihypertension efficacy and compliance of nifedipine gastrointestinal therapeutic system (GITS) with enalapril and nifedipine. METHODS: In a randomized single blind prospective study, after a placebo run in period, 130 patients with hypertension (M=80, F=50, age 30-72 y) were assigned to nifedipine GITS (A, n =45), enalapril (B, n =42) and nifedipine (C, n =43) treatment groups, investigated over a period of 12 mo. RESULTS: There were no significant differences of age and blood pressure between groups. The antihypertension trough peak ratio was measured in group A (101±12)%, B (65±9)% and C (36±9)%, respectively. The antihypertension effectiveness and compliance were 93 3% and 86 6%, 76 2% and 54 8%, 65 1% and 34 9%, respectively in group A, B, C. The antihypertension effectiveness or compliance correlated significantly the trough peak ratio respectively in group A ( r =0 83, 0 79), B ( r =0 80, 0 76), C ( r =0 78, 0 77). There were significant defferences, to compare the antihypertension trough peak ratio or efficacy and compliance between the group A and B or C. CONCLUSION: Nifedipine GITS are effective, safe, reliable and well tolerance in treating hypertension.
出处
《中国临床药学杂志》
CAS
2001年第6期354-357,共4页
Chinese Journal of Clinical Pharmacy
