摘要
目的 :探讨周围神经卡压损伤后组织学改变与卡压时间的关系。方法 :60只SD大鼠随机等分为 4组 (n =15 ) ,其中 4 5只制备成神经卡压模型 ,A组 :神经卡压 1周后去除硅胶管 ;B组 :神经卡压 2周后去除硅胶管 ;C组 :神经卡压 3周后去除硅胶管。D组 :只分离神经不进行卡压。各组分别于去除卡压后不同时间取材进行组织形态学观察。结果 :各组神经卡压区域均发生不同程度的轴突肿胀和阶段性脱髓鞘改变 ,卡压时间越长病理变化越重。卡压松解后 1～ 5周 ,A组卡压区域和远端的脱髓鞘改变与B、C组相比明显减轻。结论 :周围神经卡压损伤程度与卡压时间成正比 ,及早去除卡压有利于损伤神经再生与修复。
bjective:To investigate the re1ation between the extent of morphological changes and time of nerve compression. Method: Sixty SD rats were randomly divided into 4 groups of 15. Forty five were used for the animal mode1 of sciatic nerve compression. Group A: compression for l week; group B: compression for 2 weeks; group C: compression for 3 weeks; group D: simple operation without nerve compression. The morphological changes were observed in the three groups. Result: The pathological changes were axonal edema and segmental demyelination at different extent which were observed at the compression segment and the segment dista1 to compression in all groups. The changes were aggravated as the time of compression prolonged. After decompression for 1～5 week, changes of demyelination became weaker in the area of compression and dista1 to compression in group A as compared to group B and C. Conclusion: The nerve injury induced by nerve compression was in proportion to the time of compression. An early decompression could accelerate the regeneration and repairs for the injured nerve.
出处
《中国疼痛医学杂志》
CAS
CSCD
2001年第4期199-202,共4页
Chinese Journal of Pain Medicine
