摘要
目的 :探讨血浆组织型纤溶酶原激活物 (t -PA)及其抑制物 (PAI -1)、血栓调节蛋白 (TM )和血小板α颗粒膜蛋白 -14 0 (GMP -14 0 )在急性脑梗死发病中的意义。方法 :对 5 7例急性脑梗死患者进行血浆t -PA、PAI -1、TM及GMP -14 0的检测 ,并与对照组进行比较。结果 :急性脑梗死患者较正常对照组t -PA水平明显降低 ,PAI -1、TM及GMP -14 0水平明显升高 (P <0 0 1)。结论 :急性期脑梗死患者内皮细胞损伤、血小板活化及纤溶活性的变化可能参与了疾病的发生发展过程 。
Objective:To study the effects of tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1 (PAI-1),thrombomodulin(TM)and platelet alpha granule membrance protein-140(GMP-140) in patients with acute cerebral infarction(CI).Methods:Plasma t-PA,PAI-1,TM and GMP-140 were determined in 57 patients with acute CI and compared with the controls.Results:The level of t-PA was significantly lower and the levels of PAI-1,TM and GMP-140 were significantly higher in acute CI group than in the control group(P<0 01).Conclusion:Endothelial cell injury,platelets activation and altered fibrinolytic activity in patients with acute CI may be involved in the development of CI,the results provide a theoretical basis for the therapy in patients with acute CI.
出处
《江苏临床医学杂志》
2001年第5期384-386,共3页
Journal of Jiangsu Clinical Medicine
