摘要
为探讨新生儿期血清胆红素水平对远期预后的影响 ,对 1 2 6例高胆红素血症患儿在 5～ 8岁时进行智力、听力及神经系统随访检查。结果发现 ,3 3例患儿有程度不等的智力缺陷 ,2 5例有听力损失 ,6例有神经系统的改变。智力、听力及神经系统异常率与血清总红素峰值无显著相关性 (P >0 0 5)。溶血组与非溶血组间异常率无显著性差异 (P >0 0 5)。结果提示 ,除重度高胆红素血症外 ,轻、中度高胆红素血症 (无论是否溶血 )也可对新生儿产生永久性神经损害 ,致精神神经发育异常 ,仅凭血清胆红素水平并不能确切预测远期预后。对所有高胆红素血症新生儿均应积极治疗 ,尽量减少后遗症的发生。
To study the effect of serum bilirubin level on long-term prognosis in neonates with hyperbilirubinemia. 126 babies with hyperbilirubinemia were surveyed. All cases 5-8 years old were examined in intelligence, hearing and nervous system. Results showed that 33 cases had intelligence deficiency at different degree, 25 cases had hearing loss and 6 cases had abnormality in nervous system. There wasn't obvious correlation between abnormal rate in intelligence, hearing and nervous system and the peak value of total bilirubin (P>O. 05). There wasn't significant difference between the abnormal rate of hemolytic group and nonhemolytic group(P>O. 05). Conclusion: mild, moderate, and serere hyperbilirubinemia (whether hemolytic or not) will produce permanent nervous impairment in neonates and cause psychoneurologic abnormality. Long-term prognosis couldn't be exactly prediceted merely depending on the total level of bilirubin. All neonates with hyperbilirubinemia must be actively treated to reduce sequela to the minimum.
出处
《新生儿科杂志》
2001年第6期251-252,247,共3页
The Journal of Neonatology
