摘要
目的 观察果糖治疗不稳定性心绞痛的疗效 .方法 138例患者随机分为果糖组 (70例 )和对照组 (6 8例 ) ,观察心绞痛发作次数 ,12导联心电图变化和心脏事件发生次数(心肌梗死、猝死、严重的心律失常 ) .结果 心绞痛发作次数 :果糖组和对照组明显低于治疗前 (P<0 .0 1) ,治疗后果糖组也明显低于对照组 [(0 .6 8± 0 .5 7)次· d- 1 vs(1.0 4± 0 .81)次· d- 1 ,P<0 .0 1];12导联心电图改善的比较 :果糖组 (4 9/70例 )明显优于对照组 (36 / 6 8例 ,P<0 .0 5 ) ;心脏事件发生上 ,果糖组明显低于对照组 (8/ 70例比 17/ 6 8例 ,P <0 .0 5 ) .
AIM To evaluate the clinical effect of fructose 1,6 diphosphate in unstable angina (UA). METHODS 138 patients with unstable angina were randomized into fructose 1,6 diphosphate group ( n =70) and control group ( n =68). The frequency of angina, electrocardiogram (ECG) and cardiac events (myocardial infarction, sudden death, and serious arrhythmia) were observed. RESULTS Frequency of angina was decreased significantly post therapy than pre therapy. Compared with control group, the frequency of angina [( 0.68 ±0.57) d -1 to (1.04±0.81) d -1 , P <0.01] and cardiac events (8/70 to 17/68, P <0.05) were decreasedsignificantly in fructose1,6 diphosphate group. The improvement of ECG in fructose group (49/70) were more obvious than that in control group (36/68, P <0.05). CONCLUSION fructose 1,6 diphosphate shows a good curative effect in UA.
出处
《第四军医大学学报》
北大核心
2001年第21期1973-1975,共3页
Journal of the Fourth Military Medical University
