摘要
目的 探讨急性有机磷农药中毒 (AOPP)时抗胆碱药和氯解磷定的用量和用法。方法 AOPP患者 5 2例分为两组 ,阿托品组 2 2例 ,用阿托品 +氯解磷定治疗 ;长效托宁组 3 0例 ,用长效托宁 +氯解磷定治疗 (均肌内注射 )。两组患者分别采用推荐首次用药量 ,再根据胆碱酯酶 (ChE)活力确定重复用药剂量。ChE活力达 5 0 %以上为停药观察指标。结果 阿托品组轻、中、重度中毒患者的阿托品用药总量分别为 ( 11.0± 2 .6)mg、( 2 6.3± 1.6)mg、( 5 4 .3± 1.3 )mg ;氯解磷定用药总量分别为 ( 1.2± 0 .8)g、( 1.9± 1.5 )g、( 3 .2± 0 .9)g;治愈时间分别为 ( 1.8± 0 .3 )d、( 1.9± 0 .6)d、( 3 .5± 0 .5 )d。长效托宁组轻、中、重度中毒患者的长效托宁用药总量分别为 ( 5 .0± 0 .4 )mg、( 9.0± 1.5 )mg、( 10 .0± 0 .3 )mg;氯解磷定用药总量分别为 ( 1.7± 1.0 )g、( 2 .1± 0 .7)g、( 3 .9± 1.2 )g;治愈时间分别为 ( 1.4± 1.5 )d、( 2 .0± 0 .1)d、( 2 .6± 0 .8)d。结论 急性有机磷农药中毒时以抗胆碱药联合应用氯解磷定肌内注射 ,并根据ChE活力结果指导用药 ,方法简单 ,用药总量小 ,治疗效果好。
Objective To explore the using dosage and method of anticholine drug combined with pralidoxime chloride(2PAM·Cl) for acute organophosphorus pesticide poisoning(AOPP). Methods 52 patients with AOPP were divided into two groups:(1)atropine group(atropine+2PAM·Cl) 22 cases;(2)long acting Tuo Ning group(long-acting Tuo Ning+2PAM·Cl) 30 cases.After the first recommended dose,the repeated doses were based on the activity of ChE.ChE activity>50% was the sign to stop drug administration.THZ] Results In atropine group,the total using dosages of atropine for mild,moderate and severe AOPP patients were(11.0±2.6),(26.3±1.6) and (54.3±1.3)mg respecitvely,and those of 2PAM·Cl were (1.2±0.8),(1.9±1.5) and (3.2± 0.9)g respectively,the cure time were (1.8± 0.3),(1.9±0.6),(3.5±0.5)d respectively;In long-acting Tuo Ning group,the total using dosages of long-acting Tuo Ning for mild,moderate and severe AOPP patients were (5.0± 0.4),(9.0±1.5),(10.0± 0.3)mg respectively and those of 2PAM·Cl were (1.7±1.0),(2.1±0.7), (3.9±1.2)g respectively,the cure time was (1.4±1.5), (2.0±0.1), (2.6±0.8)d. Conclusion Combined use of anticholine drug with 2PAM·Cl for AOPP by im injection and according to the change in ChE activity as a guide to using drug may have the advantages of simple manage,small total dosage and good therapeutic effect. Results In atropine group,the total using dosages of atropine for mild,moderate and severe AOPP patients were(11.0±2.6),(26.3±1.6) and (54.3±1.3)mg respecitvely,and those of 2PAM·Cl were (1.2±0.8),(1.9±1.5) and (3.2± 0.9)g respectively,the cure time were (1.8± 0.3),(1.9±0.6),(3.5±0.5)d respectively;In long-acting Tuo Ning group,the total using dosages of long-acting Tuo Ning for mild,moderate and severe AOPP patients were (5.0± 0.4),(9.0±1.5),(10.0± 0.3)mg respectively and those of 2PAM·Cl were (1.7±1.0),(2.1±0.7), (3.9±1.2)g respectively,the cure time was (1.4±1.5), (2.0±0.1), (2.6±0.8)d. Conclusion Combined use of anticholine drug with 2PAM·Cl for AOPP by im injection and according to the change in ChE activity as a guide to using drug may have the advantages of simple manage,small total dosage and good therapeutic effect.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2001年第4期287-288,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
有机磷农药中毒
氯解磷定
抗胆碱药
治疗
Organophosphorus pesticide
Poisoning
Pralidoxime chloride
Anticholine drug
