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去白细胞处理对全血保存中IL-2和IL-8水平的影响 被引量:4

The effect of leukoreduction on the IL-2 and IL-8 leveIs in blood storage
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摘要 目的:研究全血在保存过程中是否存在IL-2和IL-8的积累,保存前白细胞滤除对其保存水平的影响。方法:选10名健康捐血者,各采集 200ml全血分成2袋,其中一袋经去白细胞处理。在4℃保存不同时期测定血液中 IL-2、IL-8含量的动态变化。结果:随着保存,全血中IL-2和IL-8的浓度不断增高。经去白细胞处理后,IL-8水平在保存中无明显变化,IL-2的含量仍然增高,但在保存期末低于正常全血中的相应含量。结论:IL-2和IL-8在全血保存中存在产生和累积,而去白细胞过滤可以抑制IL-2和IL-8在全血保存中存在产生和累积,而去白细胞过滤可以抑制IL-8的升高,对预防发热性非溶血性输血反应有一定作用。 Investigate the effect of prestorage white cell filtration on the cytokines content in blood. Methods: Ten units of whole blood was divided into two parts just after blood collection:one was used as control, the other was filtrated by leukoreduction filters. All units were stored at 4℃ for 6 weeks. Immediately after filtration and every week subsequently, samples for analses of IL-2, IL-8 were obtained. Results:The amounts of IL-2 and IL-8 increased during the storage period. In filtered units, the amounts of IL-8 did not increase during the study period, IL-2 still increased but was still lower than that of unfiltered units at the end of storage. Conclusion: Many cytokines, such as IL-2 and IL-8, were generated and accumulated in blood during blood storage. Leukocyte filtration may prevent this effect to some extend. Prestorage filtration may decrease FNHTRs by preventing the accumulation of cytokines in blood.
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2002年第1期54-55,共2页 Chinese Journal of Immunology
基金 全军"十五"医药卫生重大项目指令性课题(01L045)
关键词 去白细胞过滤 细胞因子 白细胞介素2 白细胞介素8 全血保存 IL-2 IL-8 Prestorage leukoreduction Cytokine IL-2 IL-8
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参考文献5

  • 1Sacher R A,Boyle L,Freter C E.High circulating IL and levels associated with acute transfusion reaction:cause or effect[].Transfusion.1993
  • 2Hammer J H,Mynster T,Reimert C M et al.Reduction of biosctive sub stances in stored donor blood: prestorage versus bedside leucofiltration[].European Journal of Haematology.1999
  • 3You A,Kitagawa S,Kashara T et al.Stimulation and priming of human neutrophils by IL-8 cooperation with TNF and colony stimulating factors[].Blood.1991
  • 4Hoffman M.Antibody-coated erythrocytes induce secretion of TNF by human monocytes: a mechanism for the production of fever by incompatible transfusion[].Vox Sanguinis.1991
  • 5Meddle N M,Klama L,Singer J et al.The role of the plasma from platelet concentration in transfusion reactions[].The New England Journal of Medicine.1994

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