摘要
目的 探讨癌细胞侵润转移机理。方法 取 8例人直肠腺癌的癌周组织和转移淋巴结以及 5例正常人的直肠组织和淋巴结 ,采用免疫组织化学方法检测其细胞核转录因子 κB(nuclear factorκB,NFκB)的表达。结果 癌周直肠组织中的癌细胞以及转移淋巴结的癌细胞中均有 NFκBp6 5的表达。结论 癌细胞的侵润转移的生物学性质与
Objective Nuclear factorκB is very important in cis activation which regulates the expression of many genes. This study inquired into the mechanism of cancer cell metastasis. Methods Immunohistochemical method was used for studying the expression of nuclear factorκB in cancer cells of human metastasized rectum adenocarcinoma. Results Expressed nuclear factorκBp65 was found in the cancer cells of peritumoral tissues and metastasized lymph nodes.The reaction product was located in the cytoplasm and cytonucleus. Conclusion The findings of this study suggest a strong correlation between the expression of nuclear factorκB in cancer cells and the metastasis of cancer.
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2002年第1期23-24,27,共3页
Journal of West China University of Medical Sciences
