摘要
目的：了解北京地区幽门螺杆菌（Ｈｐ）的临床耐药情况以及耐药菌株对Ｈｐ根除治疗的影响。方法：对１０８例Ｈｐ阳性患者的临床分离株，采用Ｅ－ｔｅｓｔ方法测定幽门螺杆菌对甲硝唑、克拉霉素和阿莫西林的敏感性；并用７ｄ三联疗法或３ｄ四联疗法分别对其中４１位十二指肠溃疡患者予幽门螺杆菌根除治疗。结果：１０８株幽门螺杆菌菌株中，对甲硝哇耐药率为３７．０％，对克拉霉素耐药率为１３．０％，对其中１８株幽门螺杆菌菌株进行了阿莫西林的药物敏感试验，发现 １例耐药，７ｄ疗法和３ｄ疗法对幽门螺杆菌敏感株的根除率分别为９１．７％及８０．０％，耐药株的根除率分别为４０．０％及２５．０％。结论：幽门螺杆菌对甲硝唑、克拉霉素和阿莫西林均有耐药出现，其中以甲硝唑耐药率最高，克拉霉素的耐药率也呈增高趋势，耐药菌株的出现是导致幽门螺杆菌根除治疗失败的主要原因之一。
OBJECTIVE: To investigate the prevalence of antibiotic resistant Helicobacter pylori (H. pylon) strains among Chinese patients in Beijing. To studythe influence of resistant H. pylon strains on efficacy of eradication therapy. METHODS: To value the susceptibility of H. pylon strains isolated from 108 patients by E-test. To cure H. pylon infection in 41 duodenal ulcer patients by using one-week triple therapy or three-day quadruple therapy. RESULTS:Metronidazole resistant H. pylon strains were found in 37.0% of patients, and clarithromycin resistant strains were 13.0%. One of 18 patients had amoxicillin-resistant strain of H. pylon. In patients with sensitive strains versus resistant strains, the cure rates were 91.7% versus 40. 4% with one-week triple therapy, 80.0% versus 25.0% with three-day quadruple therapy. CONCLUSION:Resistance rate to metronidazole is highest, and to clarithromycin is increased. Resistance against amoxicillin is still rare. H. pylon resistance reduced the efficacy of eradication therapy.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2001年第6期415-418,共4页
The Chinese Journal of Clinical Pharmacology
关键词
幽门螺杆菌
甲硝唑
克拉霉素
阿莫西林
耐药性
根除治疗
Helicobacter pylori
antibiotic resistance
metronidazole
clarithromycin
amoxicillin
