摘要
目的：研究抗高血压药物在大范围人群应用效果、药物不良反应及影响因素，促进高血压人群的合理用药。方法：建立了一个社区人群抗高血压药物监测系统。统计血压控制率和药物不良反应，运用非条件ｌｏｇｉｓｔｉｃ回归分析，对２７个变量进行因素分析。结果：高血压人群的血压控制率很低（１３．４８％）；服药依从性差、四药以上联合、糖尿病、吸烟、药物不良反应、心脑血管病是血压控制率主要的独立危险因素；文化程度高、有经济来源、二药联合、非药物治疗是社区高血压人群血压控制率的保护因素。其中二药联合、非药物治疗是主要的独立保护因素。由各组药物不良反应发生情况看，不规则用药组不良反应发生次数远大于规则用药组；四药以上联合、服药依从性差是药物不良反应发生的主要独立危险因素；二药联合、非药物治疗是药物不良反应发生的独立保护因素。
OBJECTIVE:To learn the controlled ratio of hypertension, adverse drug reactions and influence factors of hypertensive population in community. METHODS:We investigated blood pressure controlling ratio and ADR in hypertensive population, and analyses influence factors in logistic regression. RESULTS:The controlled ratio is low (13.48%); poor compliance, combined four and more drugs, diabetes, smoking, ADR, cardiovascular diseases are independent dangerous factors of controlled ratio; combined two drugs, and non-pharmacological treatments are independent protective factors of controlled ratio;the incidence of ADR in taking medicine irregularly is higher than the one of taking medicine regularly. Combined four and more drugs, poor compliance are independent dangerous factors of ADR. Combined two drug, non-pharmacological treatments are independent protective factors of ADR.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2001年第6期434-439,共6页
The Chinese Journal of Clinical Pharmacology
