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葡萄球菌烫伤样皮肤综合征的研究进展 被引量:75

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摘要 表皮剥脱毒素是葡萄球菌烫伤样皮肤综合征的病因 ,可能直接作用于桥粒和 (或 )作为超抗原引起表皮松解。葡萄球菌烫伤样皮肤综合征好发于儿童而罕见于成人 ,可能与成人循环中表皮剥脱毒素抗体浓度较高和肾脏代谢与排泄毒素能力较强有关。本病的诊断目前主要依赖于临床 ,确诊需行金黄色葡萄球菌噬菌体分组和表皮剥脱毒素检测。耐 β 内酰胺酶抗生素有良好疗效。儿童病例的死亡率为 3%~ 4 %。
出处 《国外医学(皮肤性病学分册)》 2002年第1期22-24,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
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  • 1Farrell AM. Staphylococcal scalded-skin syndrome. Lancet, 1999, 354(9182): 880-881.
  • 2Ladhani S, Evans RW. Staphylococcal scalded skin syndrome. Arch Dis Child, 1998 ,78(1) :85-88.
  • 3Fitzpatrick TB, et al. Dermatology in general medicine .4th ed . New York : McGraw-Hill, 1993.601-605.
  • 4Acland KM, Darvay A, Griffin C, et al. Staphylococcal scalded skin syndrome in an adult associated with methicillin-resistant Staphylococcus aureus. Br J Dermatol, 1999,140(3) :518-520.
  • 5Rago JV, Vath GM, Tripp TJ, et al. Staphylococcal exfoliative toxins cleave alpha- and beta-melanocyte-stimulating hormones. Infect Immun,2000,68(4) :2366-2368.
  • 6Vath GM, Earhart CA, Monie DD, et al. The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity. Biochemistry, 1999,38(32): 10239-10246.
  • 7Lina G, Gillet Y, Vandenesch F, et al. Toxin involvement in staphylococcal scalded skin syndrome. Clin Infect Dis, 1997 , 25 ( 6 ): 1369-1373.
  • 8Ladhani S, Joannou CL, Lochrie DP, et al. Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scaldedskin syndrome. Clin Microbiol Rev, 1999 , 12(2) :224-242.
  • 9Rago JV, Vath GM, Bohach GA, et al. Mutational analysis of the superantigen staphylococcal exfoliative toxin A (ETA). J Immunol, 2000, 164(4) :2207-2213.
  • 10Ninomiya J, Ito Y, Takiuchi I. Purification of protease from a mixture of exfoliative toxin and newborn-mouse epidermis. Infect Immtm, 2000, 68(9) :5044-5049.

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