摘要
目的 :探讨长效 β2 -肾上腺素能受体激动剂formoterol(福莫特罗 )在哮喘治疗中的抗炎途径。方法 :2 8例轻、中度发作期哮喘患者被随机分为两组 :formoterol治疗组 1 4例 ,40 μg每日 2次 ,口服 ;procaterol(丙卡特罗 )治疗组 1 4例 ,50 μg每日 2次 ,口服 ,疗程 4周。治疗前后ELISA法测定血清IL - 8含量 ,同时测定肺通气功能。结果 :哮喘患者血清IL - 8含量显著升高与同时测定的肺通气功能结果呈显著负相关(P <0 0 2 )。formoterol治疗组血清IL - 8含量由治疗前的 (342 60± 1 35 69) pg/ml降至治疗后的 (1 70 93± 82 83) pg/ml,差异有显著性 (P<0 0 0 5) ;procaterol治疗组血清IL - 8含量由治疗前的 (2 93 90± 1 1 6 2 0 ) pg/ml降至治疗后的 (2 32 0 0± 1 1 2 72 )pg/ml,差异无显著性 (P >0 0 5)。两组IL - 8治疗前后的差值比较差异有显著性 (P <0 0 1 )。结论 :formoterol治疗组IL - 8下降更为明显 。
Objective:To evaluate the anti-inflammatory effect of formoterol.Methods:28 patients with asthma on their acute attacks were divided into 2 groups,14 patients were administed formoterol 40 μg bid by taking orally and another 14 patients took procaterol 50 μg bid orally for four weeks.The concentration of IL-8 in serum of the 28 patients with asthma on their acute attacks were measured with ELISA method before and after treatment,meanwhile pulmonary function was measured.Results:It was found that in patients with asthma,IL-8 was significantly higher than that in normal subjects (P<0 001).After treatment with formoterol,the decreases in IL-8 concentration was 50 11%,while the decreases in another group treated with procaterol was 20 23%,the difference between the two treatment groups was significant (P<0 01)。Conclusions:IL-8 concentration of the two groups decreased after their treatment,but it was more remarkable in formoterol group than in procaterol group.It is concluded that the result may be related to the antiinflammatory effect of formoterol.
出处
《中国冶金工业医学杂志》
2001年第5期259-261,共3页
Chinese Medical Journal of Metallurgical industry
