摘要
目的:评价第三代β受体阻滞剂——卡维地洛治疗稳定型心绞痛(SA)的临床疗效。方法:选择SA患者共126例,随机分为卡维地洛治疗组(n=66)和倍他乐克对照组(n=60),观察用药4周后的治疗有效率以及心肌耗氧量(RPP)和血浆C反应蛋白(CRP)浓度的变化。结果:用药后①治疗组临床总有效率明显高于对照组,为93.94％比80.00％(P<0.05)。②治疗组RPP明显减少,用药前后为(1491±225)Kpa·次/分比(1232±211)Kpa·次/分(P<0.05);而对照组无明显差异,用药前后为(1500±270)Kpa·次/分比(1499±115)Kpa·次/分(P>0.05)。③治疗组血浆CRP浓度明显降低,用药前后为(5228±518)μg/L比(2390±201)μg/L(P<0.05);而对照组则无明显变化,用药前后为(5218±520)μg/L比(5216±519)μg/L(P>0.05)。④治疗组较对照组心血管危险事件发生率明显降低(P<0.05)。结论:卡维地洛是一种具有α_1受体阻滞作用和抗炎作用的β-肾上腺素能受体阻滞剂,临床治疗SA疗效显著。
Objective: To evaluate the clinical effect of carvedilol which the third - generation β - blocker treated patients of stable angina(SA). Method: 126 patients of SA were randomly divided into two groups, one is the treatment group (n = 66) which was treated with carvedilol, the other is the control group (n = 60) which wag treated with betaxolol, and the clinical effective treatment, the rate pressure product (RPP) and the plasma C-reactive protein (CRP) concentration were observed after treated four weeks. Result: After treated ① the clinical effectiveness of the trentment group was significantly higher than the control group (93.94% vs 80.00% , P < 0.05) .②RPP of the treatment group was significantly decrease than that before treated (1491±225) Kpa·beats/ min vs (1232±211)Kpa· beats/min,P< 0.05) , but it was not significantly difference in the control group. (1500±270)KPa· beats/min vs (1499± 115)KPa·beats/min, P>0.05) ③the plasmea CRP concentration of the treatment group was significantly lower than that before treated (5228±518) μg/L vs (2390±201) μg/L, P < 0.05), but it was not significantly difference in the control group (5218± 520)μg/L vs( 5216± 519)μg/L, P > 0.05)④the cardiovascular episodes of the treatment group were significantly decrease than that of the control group (P < 0.05) . Conclusion: carvedilol was a β - adrenergic receptor blocker which has roles of α1 receptor block and inhibition of inflammation, and the clinical effect of treatment in SA was significant
出处
《中国医药导刊》
2001年第4期278-279,共2页
Chinese Journal of Medicinal Guide
