摘要
目的 :通过CD44V6 ,RB ,C myc基因表达 ,探讨三种基因蛋白对胰腺肿瘤的发生及预后的影响。 方法 :采用免疫组化S P法。结果 :RB基因胰腺癌表达率为 35 .0 % ,胰腺炎为 80 % ;C myc胰腺癌表达率为 5 0 6 % ,胰腺炎为 0 % ,和癌比较有统计意义 (P <0 0 5 ) ;CD44V6在胰腺癌中表达率为 6 8 2 % ,胰腺炎为 2 0 0 % ,有组间差异 (P <0 0 5 )。结论 :CD44V6 ,C myc参与胰腺癌的发生过程 。
Objective:To study the expression of CD44V6,RB and C myc genes and determine whether the three genes were related to pancreas carcinogenesis and prognosis.Methods:S P method was used.Results:Tho positive rate of RB gene in pancreatitis and carcinoma of pancreas was 80% and 35% respectively. In the pancreatitis,the expression of C myc was not detected but detected in 50.6% of carcinoma of pancreas,there was significant difference(P<0 05) between two groups. The expression of CD44V6 was found in 20% of pancreatitis and 68.2% of carcinoma of pancreas,there existed significant difference(P<0 05) between the groups.Conclusion:CD44V6,C myc was involved in the course of pancreas carcinogenesis detecting the genes was helpful to pancreas tumor development and prognosis.
出处
《内蒙古医学院学报》
2001年第3期167-169,共3页
Acta Academiae Medicinae Neimongol
