摘要
目的:探索黄酮醋酸类化合物中间体的合成方法。方法:通过酰基化、Fries重排、氯甲基化合成2-羟基-3-氯甲基-5-甲基苯乙酮,并应用(HCHO)n/HCI系统进行氯甲基化,获得了满意的收率(90.4%)。结果:采用新方法合成了未见文献报道的新化合物2-羟基-3-氯甲基-5-甲基苯乙酮。结论:该方法具有反应时间短、操作简便、收率好等优点。
Objective: To study the synthetic methods of the intermediate products of the substituted flavone-8-acetic acids. Methods: The synthesis has been finished by acylating,Fries rearrangement reaction and chloromethylating. Meantime ,the good yield (90.4%) has been obtained the system of (HCHO)n/HCl to chloromethylate. Results: By the new method,2-hydroxy -3- chloromethyl -5- methyl atopenone was synthesized, which has not been reported yet. Conclusions: This method is charactered by the reaction time being short, the operation process being simply and the yield being good.
出处
《黑龙江医药科学》
2001年第6期24-25,共2页
Heilongjiang Medicine and Pharmacy
