摘要
目的 :制备布比卡因聚乳酸缓释微球 ,并对其体外释药特性进行考察。方法 :以聚乳酸为载体 ,采用 W/O/W乳剂 -扩散溶剂挥发法制备布比卡因聚乳酸缓释微球 ,考察了微球的粉粒学特征 ,并进行了体外溶出研究。 结果 :差热分析表明 ,布比卡因在载体中以分子状态存在 ,与聚乳酸形成了包嵌的微球体 ;其体外释药曲线可用 Higuchi方程拟合 ,t1 /2 =2 2 .76 h。 结论 :布比卡因聚乳酸缓释微球体外具有缓释作用。
Objective: To prepare sustained-release polylactic acid microspheres containing bupivacaine (BUP-PLA-MS) and to measure its dissolution in vitro. Methods: BUP-PLA-MS was prepared with polylactic acid (PLA) as carriers using the water-in-oil-in-water (W/O/W) emulsion solvent evaporation method. The powder particle characteristics of BUP-PLA-MS were evaluated comprehensively, and its dissolution characteristics in vitro were studied. Results: It was indicated that bupivacaine formed molecular dispersion within PLA matrix by differential thermal analysis(DTA). The in vitro release behavior of bupivacaine could be best described by Higuchi equation, with t 1/2 =22.76 h. Conclusion: Release of bupivacaine from microspheres is sustained in vitro.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第1期87-89,共3页
Academic Journal of Second Military Medical University
