摘要
目的 探讨血浆一氧化氮(NO)浓度与抑郁症之间的关系。方法 采用硝酸还原酶法对34例抑郁症患者血浆一氧化氮(NO)浓度进行检测,并与正常对照组比较。结果 抑郁症患者血浆一氧化氮(NO)浓度为20.79±12.80μmol/L,低子正常对照组30.68±13.56μmol/L,存在显著性差异(t=3.393,P<0.001);治疗前后比较,治疗前血浆一氧化氮(NO)浓度(20.77±14.80)μmol/L低于治疗后(28.33±22.52)μmol/L,但无显著性差异(t=-1.313,P=0.203)。血浆一氧化氮(NO)浓度与年龄、病程和家族史等无相关性。结论 一氧化氮(NO)可能在抑郁症的发病机制中起一定作用。
Objective To explore the relationship between depression and plasma nitric oxide (NO).Methods Plasma NO Levels were measured in 34 depressions and 53 controls. Results The Plasma NO Levels in the depression group was lower than those in control group. The difference (20.79±12.80umol/L vs 30.68+13.56umol/L, P < 0.001) was significant. The Plasma NO Levels in drug-free depressive condition was lower than those after treatment, but no significantly difference (20.77±14.80umol/L vs 28.33±22.52umol/L,P= 0.203),Conclusion Nitric oxide (NO) may play a role in the pathogenesis of depression.
出处
《山东精神医学》
2001年第4期224-225,共2页
Shangdong Archives of Psychiatry
