摘要
目的：观察胸腺肽注射液对成人急性病毒性心肌炎（VMC）细胞免疫功能失调患者的短期疗效。方法：86例VMC患者有不同程度的T淋巴细胞亚群及自然杀伤细胞（NKC）活性异常，随机分为对照组40例及治疗组46例，对照组给予GIK极化液静滴，口服辅酶Q10等常规治疗，治疗组在对照组治疗用药基础上加用胸腺肽注射液100mg，每天静滴，疗程2周，疗程结束后复查T淋巴细胞亚群及NKC活性，并比较两组症状改善情况。结果：治疗组治疗后CD3^+,CD4^+,CD8^+及NKC活性较治疗前及对照组治疗后均显著升高（P＜0．05），且治疗组在乏力，纳差，胸闷，心悸,盗汗症状的改善功效方面优于对照组。结论：急性VMC患者多存在不同程度的细胞免疫功能低下，可对其疗效，病情的反复或迁延产生影响，应予积极纠正，胸腺肽注射液短期疗效，肯定。
Objective\ To observe the short-time effect of thymopeptidum injection on patients with cellular immune dysfunction of adult acute myocarditis.Method\ 86 VMC patients with abnormal activity of T-lymphocyte subgroup and NKC were divided randomly into control group (40 cases) and treatment group (46 cases).Control group received basic therapy of GIK,CoQ 10 ,the treatment group received thymopeptidum injection 100 mg per day intravenously for 2 weeks,besides the basic therapy.After treatment.Tested the activity of T-lymphocyte subgroup and NKC,and compared the symptoms improvement between the two groups.Results\ In treatment group,CD + 3\,CD + 4\,CD + 8 and NKC activity increased obviously compared with that of before therapy and in control group (P<0.05);The improvement of fatigue,inappetence,stuffy,palpitation,night or spontaneous sweat was better than in control group.Conclusion\ Most acute VMC patients had cellular immune dysfunction,it may influence the curative effect,symptom fluctuant and illness prolonging.It should be corrected.The short-time curative effect of thymopeptidum was safe and confirmed.
出处
《医师进修杂志》
北大核心
2001年第12期16-17,共2页
Journal of Postgraduates of Medicine
