摘要
目的 :观察慢性低氧及低氧游泳大鼠心肌糖原含量的变化 ,探讨其与右心舒缩功能升降的关系。方法 :采用低压舱模拟海拔 5 0 0 0m连续低氧及低氧游泳大鼠模型 ,用比色法测定其心肌糖原含量 ;用右心导管法经RM - 6 0 0 0生理多导记录仪记录右心舒缩功能指标。结果 :大鼠心肌糖原含量在低氧早期即显著下降 ,随低氧时间的延长 ,呈较明显进一步下降的趋势 ,而右心功能则逐渐增强 ;低氧游泳组大鼠右心功能明显增强 ,其心肌糖原含量接近平原对照水平 ,显著高于单纯低氧组。结论 :大鼠在低氧条件下适量作功 (游泳 ) ,可能有利于机体的低氧适应。
AIM: To investigate the changes of myocardium glycogen content and the relation ship between changes of the myocardial glycogen content and the myocardial function. METHODS: Male Wistar rats were placed in (hypoxia rats) and made to swim in (hypoxia swimming rats) a hypobaxic chamber simulating an altitude of 5 000 m above sea level. The content of myocardium glycogens was determined by colorimetry. RESULTS: The myocardium glycogen content of rats significantly reduced along with the prolongation of hypoxic exposure and approached to control level in hypoxia swimming rats. The myocardial function of right ventricule was improved significantly compared with control group. CONCLUSION: Moderate exercise (Swimming) is beneficial to hypoxic adaptation of rats under the condition of chronic hypoxia.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2002年第1期21-23,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目 (No .39770 2 89)
关键词
低氧
心肌
糖原
右心室功能
Anoxia
Myocardium
Glycogen
Ventricular function, right
