摘要
目的 :观察痹肿消汤 (BZX)对类风湿性关节炎 (RA)患者外周血淋巴T细胞亚群的影响 ,从细胞免疫探讨本方药的疗效机制。方法 :选择RA活动期患者 42例 ,随机分为BZX治疗组和西药 (TMX与普威 )治疗对照组 ;2 0名健康人为正常对照组 ,于治疗前和治疗 3月后分别检测CD+4,CD+8,计算CD+4/CD+8值。结果 :治疗前RA患者外周血CD+4较正常人对照组增高 (P <0 .0 1 ) ,CD+8较正常人对照组降低 (P <0 .0 1 ) ,CD+4/CD+8值较正常人对照组升高 (P<0 .0 1 )。治疗 3月后 ,治疗两组CD+4下降 ,CD+8升高 ,CD+4/CD+8值降低 ,均接近于正常 ;两组各指标比较差异无显著性 (P >0 .0 5 )。结论 :RA患者体内存在着细胞免疫调节紊乱 ,痹肿消汤能调节T细胞分布紊乱 ,有助于机体恢复免疫稳定状态 ,具有类似MTX联合用药的免疫抑制效应。
Objective To observe the effect of BZX on T-lymphocyte subsets in the peripheral blood of patients with rheumatoid arthritis (RA) and study the mechanism of curative effects of BZX in immunization. Methods 42 patients with RA in active stage were divided into ①treatment group with BZX ② control group with western medicine and twenty healthy control group (HCG) was arranged before treatment. Their CD + 4 and CD + 8 were tested and the ratio of CD + 4 cells to CD + 8 cells was calculated before treatment and after 3 months treatment. Results In the peripheral blood of patients with RA, CD + 4 was more than that of the HCG. but CD + 8 was lower and the ratio of CD + 4 cell to CD + 8 cells was higher than that of the HCG. After 3 months treatment, CD + 4 decreased, CD + 8 increased and the ratio of CD + 4 cells to CD + 8 cells decreased. In addition, all results were similar to the normal. We found there were no significant differences between the two treatment groups in the results after treatment. Conclusion There were cell immunoregulation disorders in patients with RA. BZX can regulate the disorder of T-lymphocyte subsets, help rebuild the immune steading and have effects of immune suppression similar to MTX combined medicine.
出处
《湖南医科大学学报》
CSCD
北大核心
2001年第6期534-536,共3页
Bulletin of Hunan Medical University
基金
湖南省中医管理局课题基金 ( 2 0 0 0 0 5 3)。
