摘要
目的 探讨造成流产、死胎、不孕(不育)、闭经和出生缺陷等生殖异常的细胞生物学原因。方法 对我院1999年6月～2001年6月780例优生遗传咨询者外周血G带染色体进行分析。结果 染色体异常占受检人数的4.5％(35/780)(男性25例,女性患者10例);染色体异态,占受检人数的9.6％(75/780);染色体异常和异态患者中患有反复自发流产、死胎等不良妊娠者为16.4％(71/432);不孕不育为50.0％(29/58);闭经患者为9.7％(3/31)。在染色体异常核型中,数目异常占57.1％(20/35);染色体结构异常占37.2％(13/35);嵌合体占5.7％(2/35)。结论 生殖异常与染色体异常和异态有着密切的关系。
Objectives To examine tne relationship between cnromosome aberrations and various reproductive conditions, including miscarriage, stillbirth, infertility, amenorrhoea, and giving birth to babies with congenital malformations. Methods Frequencies of chromosome aberrations based on chromosome G-banding results for 780 genetic consultants to our institute from June 1999 to June 2001 were analyzed. Results Among the 780 consultants 35 (4. 5 %, male: 25; female: 10) had chromosome aberrations, and 75 (9.6 %) had abnormal chromosome shapes. Among those with chromosome aberrations 71 (16. 4 %) showed recurrent miscarriage or stillbirth. 29 (50.0 %) out of 58 cases with infertility, and 3 (9.7 %) out of 31 cases with amenorrhoea, showed chromosome aberrations. Among those with chromosome aberrations, 20 (57. 1 %) cases were due to aberration in chromosome number, 13 (37.2 %) cases chromosome structure, and 2 (5. 7 %) cases chromosome mosaic. Conclusions Chromosome aberrations are associated with various reproductive problems.
出处
《中国优生优育（1990-2002上半年）》
2001年第4期160-163,共4页
Journal of Improving Birth Outcome and Child Development of China
