摘要
目的 :探讨活血化瘀中药对重症肺炎患儿血中细胞因子的影响。方法 :选择入院重症肺炎患儿 40例 ,随机分为单纯西药治疗组和中西药合用组 ,并设正常对照组 12例 ,分别测定治疗前后血中肿瘤坏死因子 α(TNFα)、内皮素 1(ET 1)和超氧化物歧化酶 (SOD)活性的变化。结果 :重症肺炎患儿治疗前血中 TNFα和 ET 1比正常对照组明显升高 ,SOD活性明显下降 (P均 <0 .0 1) ;西药治疗后 TNFα和 ET 1明显下降 ,SOD明显上升 (P均 <0 .0 5 ) ;中西药合用组变化更为显著 (P均 <0 .0 1)。结论 :活血化瘀中药对重症肺炎患儿细胞因子的释放有调节作用 。
Objective:To study the effect of activating microcirculation and removing blood stasis medicinal herbs(AMRS,活血化瘀中药)on the releasing of the cytokines in the pneumonia children.Methods:Fourty patients with pneumonia children were randomly divided into two groups:western medicine group(WM, n =20),western medicine and AMRS group(WH+AMRS, n= 20),and 12 health people subject as normal control group.The contents of endothelin1(ET1),tumor necrosis factor α (TNFα)in the blood,and red blood cell superoxide dismutase (SOD) were measured respectively.Results:Before treatment,the TNFα and EF1 levels in pneumonia children were much higher than those in normal control group,as well as SOD was lower(all P <0 01).After treatment with western medicine,the TNFα,EF1 levels were decreased than those before,SOD was lower(all P <0 05).After treatment with AMRS,the TNFα and EF1 were much decreased than those before (all P <0.01).Conclusions:AMRS is able to regulate the releasing of the cytokines in the pneumonia children.So that AMRS is possesses very important protective and treatment effect on systemic inflammatory response syndrome (SIRS) and multiple organ failure(MOF).
出处
《中国中西医结合急救杂志》
CAS
2001年第5期291-292,共2页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市自然科学基金资助项目 (No.983 60 90 11)
关键词
活血化瘀药
肺炎
细胞因子
儿童
activating microcirculation and removing blood stasis medicinal herbs
pneumonia
cytokines
multiple organ failure
