摘要
目的 :完成盐酸阿呋唑嗪速释缓释双层片的处方设计及其制备。方法 :正交设计优选速释层处方 ,缓释层则以溶出百分率为考察指标。结果 :正交实验结果经统计学分析 ,确定每片速释层含有主药1mg、乳糖35mg、羧甲基淀粉钠1mg、淀粉8mg ;缓释层则为主药4mg、羟丙甲基纤维素50mg、甲基纤维素70mg。结论 :所确定的双层片处方合理 。
OBJECTIVE:To determine the formula of alfuzosin rapid-release and sustained-release bilayer tablet and its preparation METHODS:The compositions of rapid-release layer were selected by orthogonal design and the compositions of sustained-release layer were determined according to its percentage of dissolution RESULTS:The rapid-release layer contained alfuzosin 1mg,lactose 35mg,sodium carboxylmethyl starch 1mg and starch 8mg The sustained-release layer contained alfuzosin 4mg,HPMC 50mg and MC 70mg CONCLUSION:The formula of the tablet is reasonable and the preparation simple
出处
《中国药房》
CAS
CSCD
2001年第11期658-660,共3页
China Pharmacy
关键词
盐酸阿呋唑嗪
正交设计
缓释制剂
alfuzosin
orthogonal design
sustained-release tablet
