摘要
To explore the possible linkage between telomerase and acute leukemia, we detected telomerase activity expressed in 3 leukemia cell lines, 22 acute leukemia bone marrow and 6 normal bone marrow with PCR ELISA assay. Results showed that telomerase activities of three leukemia cell lines were positive with the average (1.57±0.056) U, normal bone marrow samples average was (0.085±0.081) U, telomerase value from 22 acute leukemia patients was (0.512±0.294) U. Telomerase activity is higher expressed in acute leukemia than normal samples and decreased significantly after chemotherapy(P<0.01). The results suggested that telomerase activity was related to some malignant diseases and might be used as a marker for tumor diagnosis and therapy.
To explore the possible linkage between telomerase and acute leukemia, we detected telomerase activity expressed in 3 leukemia cell lines, 22 acute leukemia bone marrow and 6 normal bone marrow with PCR ELISA assay. Results showed that telomerase activities of three leukemia cell lines were positive with the average (1.57±0.056) U, normal bone marrow samples average was (0.085±0.081) U, telomerase value from 22 acute leukemia patients was (0.512±0.294) U. Telomerase activity is higher expressed in acute leukemia than normal samples and decreased significantly after chemotherapy(P<0.01). The results suggested that telomerase activity was related to some malignant diseases and might be used as a marker for tumor diagnosis and therapy.
出处
《中国实验血液学杂志》
CAS
CSCD
2001年第4期381-382,共2页
Journal of Experimental Hematology
基金
甘肃省自然科学基金资助项目 (IS981 A2 3 0 86 Y)
兰州军区卫生部科研计划项目 (LXH 98 0 2 )~~
