摘要
应用显微电视录象技术可观察到内皮素(ET)对戊巴比妥钠麻醉的 Wistar 大鼠的肠系膜微血管有收缩作用,血液流速减慢,甚至产生微循环障碍,这个作用相当持久,并呈剂量依赖关系。ET 的这个作用远高于去甲肾上腺素。这些结果提示,ET 作为强烈的微血管收缩剂,在微循环紊乱疾病的发病学中可能具有重要意义。
By video microscope,it was observed that endothelin(ET)caused constrictionof the mesenteric microvessels of pentobarbital-anesthetized Wistar rats in a dose-dependent manner.With the consequence of causing a decrease of rate of bloodflow and even some microcirculation disorder,the action was long lasting.Theconstrictive effect of ET on microvessel was much stronger than norepinephrine.The results suggest that ET is a potent vasoconstrictor for microvessel and mayplay an important role in causing microcirculatory disorder.
出处
《生理学报》
CAS
CSCD
北大核心
1991年第1期98-101,共4页
Acta Physiologica Sinica
关键词
微血管
内皮素
血管收缩剂
endothelin
microvessel
vasoconstrictor
norepinephrine
