摘要
为探讨急性心肌梗死患者血浆脑钠尿肽动态演变的临床意义 ,将急性心肌梗死患者分为氯沙坦组、依那普利组及急性心肌梗死对照组 ,采用放射免疫法测定血浆脑钠尿肽水平 ,并与健康对照组比较 ;超声心动图测定左室舒张末容积指数和左室收缩末容积指数。结果发现 ,急性心肌梗死患者血浆脑钠尿肽水平较健康对照组升高(P <0 .0 1) ,急性心肌梗死对照组 5、14天脑钠尿肽较入院即刻进一步升高 (P <0 .0 5 ) ,而依那普利及氯沙坦组 5、14天血浆脑钠尿肽下降。前壁急性心肌梗死患者血浆脑钠尿肽高于下壁 ,再灌注者脑钠尿肽低于非再灌注者。 5天及 14天时血浆脑钠尿肽与左室舒张末容积指数、左室收缩末容积指数及血肌酸磷酸激酶峰值呈正相关。结果表明 ,急性心肌梗死患者 14天内血浆脑钠尿肽持续升高 ;脑钠尿肽升高水平可反映梗死面积及梗死膨展程度。
Aim To investigate the significance of the changes on plasm brain natriuretic peptide (BNP) in patients with acute myocardial infarction(AMI). Methods 63 patients with AMI were divided into losartan (n=19), enapril(n=23) and control (n=19) group. The plasm levels of BNP was measured in patients with AMI on admission and 24 h as well as on the day of 5 and 14, compared with ten health subjects. Left ventricular end diastolic volume index (LVEDVI) and left ventricular end systolic volume index (LVESVI) were determined by echocardiogram on the day of 5 and 14. Result The plasm levels of BNP was significantly increased on admission in control group compared with that of the health subjects(P<0.01) and increased further on the day of 5 and 14 than that on admission(P<0.05). Enapril and losartan treatment decreased plasm BNP level on the day of 5 and 14. The plasm level of BNP on the day of 5 and 14 in patients with AMI correlated with LVEDVI and LVESVI (r=0.62～0.77, P<0.01). The plasm levels of BNP levels in patients with anterior myocardial infarction (AMI) were higher than those in patients with inferior. MI and were lower in patients with early reperfusion than those with non reperfusion. Plasm levels of BNP on the day of 5 and 14 correlated with plasm peak creatine phosphokinase (r=0.32, 0.67, P<0.05, 0.01). Conclusions The plasm level of BNP increased continuously within 14 days after the onset of AMI, and this would reflect infarction area and infarction expansion post AMI.
出处
《中国动脉硬化杂志》
CAS
CSCD
2001年第4期322-324,共3页
Chinese Journal of Arteriosclerosis
关键词
急性心肌梗死
脑钠尿肽
病理
Myocardial Infarction, Acute
Brain Natriuretic Peptide
