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α-氨基酸共聚物的抗凝血性 被引量:5

Antithrombogenisity of α-Amino Acid Copolymers
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摘要 本文研究了L-白氨酸、L-谷氨酸甲酯和L-谷氨酸共聚物的侧链羧基含量对其表面性质和抗凝血性能的影响。结果表明,随着羧基含量增加,共聚物的表面张力和表面自由能均呈上升趋势。血小板粘附试验和全血凝血时间测定证实,该共聚物有较好的抗凝血性,其抗凝能力高于聚二甲基硅氧烷。 A serials of poly α-aminoacid withvarying composition of L-leucine,γ-methyl L-glutamate,γ-benzylL-glutamate and L-glutamic acidwere studied. The chemical structureand surface properties of the sampleswere examined by infrared spectro-photometry and contact anglemeasurement. The antithrombogeni-sity was evaluated by platelet adhe-ssion test and whole blood clottingtime test (Lee and White). The α- amino acid copolymers with α-helixconfiguration similar to naturalproteins are more antithrombogenicmaterials. As glutamic acid content(mole percent) in copolymers wasincreased, the critical surface ten-sion and the surface free energy wereincreased, which led to poor anti-thrombogenicity, whereas the nega-tive charges and water content onthe copolymer surfaces were increa-sed with good antithrombogenicity.In the copolymer with glutamic acid25 mole % (PLMGG-25)an optimumbalance between the hydrophilic andhydrophobic side groups was found,and its antithrombogenicity wasbetter than that of others.
机构地区 中山医科大学
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 1991年第3期209-213,共5页 Journal of Biomedical Engineering
关键词 氨基酸 共聚物 抗凝血性 poly (α-amino acid) L-leucine L-glutamate antithrombogenicity
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  • 1冯敏,潘仕荣,吴伟荣.两性霉素B/聚乙二醇-聚谷氨酸苄酯纳米球溶血毒性的研究[J].中国药科大学学报,2004,35(3):263-266. 被引量:6
  • 2潘仕荣,施锋,黄宁芳,周群,林在峰,易武.白氨酸-谷氨酸甲酯-谷氨酸共聚物的合成研究[J].生物医学工程学杂志,1997,14(2):101-104. 被引量:10
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  • 8董炎明,高分子材料实用剖析技术,1997年,80页
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