摘要
目的 了解橄榄－桥脑－小脑萎缩（ＯＰＣＡ）患者的临床特点与神经电生理改变。方法 对１６例ＯＰＣＡ患者进行多种形式的电生理检查，并结合临床表现进行分析。结果 发现ＯＰＣＡ患者视觉诱发电位（ＶＥＰ）、听觉诱发电位（ＢＡＥＰ）和体感诱发电位（ＳＥＰ）有较高的异常率，而事件相关电位Ｐ３００、肌电图（ＥＭＧ）、周围神经传导速度（ＮＣＶ）和脑电图（ＥＥＧ）无明显异常变化；临床以共济失调为核心症状伴随多种形式的神经功能异常，诱发电位检查可以发现一些亚临床病灶。结论 神经系统病理损害的广泛性是ＯＰＣＡ患者的主要特征，电生理检查对确定亚临床病灶有重要价值。
Objective To observe the clinical features and electrophysiology changes of the patients with olivo-ponto-cerebellar atrophy(OP- CA). Mothods Various electrophysiologic study(EPS) were tested in 16 patients with OPCA. The changes of EPS were analyzed in comparison with the clinical appearance. Results It was found that all patients exhibited abnormal changes in at least one of the EPS. There were high abnor- mal rates on visual evoked potential (VEP) test, brain-stem auditory evoked potential(BAEP) test and somatosensory evoked potential(SEP)test. The distinctive changes were not found on electromyography, nerve coduction velocity, electroencephalography (EEG) and event-related potentials P300. Ataxia was the main clinical manifestations coexisting multiple neurological symptoms. Conclusion Patients with OPCA have extentive damages in nervous system. Multimodal EPS have great value in determining the subclinical pathological conditions of OPCA.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2001年第8期981-983,共3页
Journal of Third Military Medical University
