摘要
目的 :评价两种方案治疗小儿原发性肾病综合征疗效。方法 :将 37例确诊为原发性肾病综合征的初治患儿 ,随机分为冲击治疗组和对照组 ,分别接受含甲泼尼龙冲击治疗的皮质激素中长程治疗和泼尼松口服中长程标准治疗。结果 :冲击治疗组的近期缓解率、复发 (反复 )率、尿蛋白阴转及血生化恢复时间均达到或优于对照组 ,冲击治疗组不良反应发生率低于对照组。结论 :含甲泼尼龙冲击治疗的皮质激素中长程方案治疗儿童肾病综合征初治病例有较大价值。
Objective: To evaluate the therapeutic effects of two regimens in treatment of children with primary nephrotic syndrome(PNS). Methods: 37 cases, who were ill with PNS and had not received any treatment, were divided into two groups. Group A received an aggresive methylprednisolone(MP) therapy followed by the moderate long term course of corticosteriod, group B received routine long term course of prednisone. Results: The therapeutic effect of group A was better than or similar to that of group B in several respects, such as remissive rate in the near future, relapse/reversal rate, disappearance of urinary protein and recovering time of serum biochemistry data. Furthermore, the side effect in group A was lower than that in group B. Conclusion: The aggresive MP therapy followed by the moderate long term course of corticosteroid is efficacious in children with PNS in the primary treatment, having a major importance.
出处
《药物流行病学杂志》
CAS
2001年第4期169-170,190,共3页
Chinese Journal of Pharmacoepidemiology
