摘要
目的 :观察冠心病患者肝叶切除围手术期血小板表面活化标志蛋白的变化。方法 :采用流式细胞技术测定 52例冠心病患者肝叶切除围手术期血小板表面活化标志蛋白 CD62 P、CD61 ( a)及血小板聚集率 ,并与术前进行对照。结果 :冠心病患者肝叶切除术后 6、1 2、2 4、4 8及 72小时 CD62 P、CD61及血小板聚集率均显著增加 ( P<0 .0 5或 P<0 .0 1 )。结论 :冠心病患者肝叶切除术后血小板呈相对激活状态 ,有利于血小板的黏附、聚集及血栓前状态的形成。
Objective:To investigate the states of platelet function during the perioperative period of hepatectomy in patients with coronary heart diseases.Methods:All patients with coronary heart diseases underwent hepatectomy and platelet membrane glycoprotein CD62P,CD61(Ⅲa) were determined by flow cytometric analysis before and 6,12,24,48,72 hours after operation.Meanwhile platelet aggregating ratio was measured before and 6,12,24,48,72 hours after operation.Results:Platelet membrane glycoproten CD62P,CD61(Ⅲa) and platelet aggregating ratio were significantly increased 6,12,24,48 and 72 hours after operation compared with preoperative period.Conclusion:Hepatectomy can lead to an increase of platelet aggregation in patients with coronary heart diseases and it may enhance platelet aggregation and thrombosis during the perioperative period.
出处
《中国危重病急救医学》
CAS
CSCD
2001年第10期607-609,共3页
Chinese Critical Care Medicine
基金
全军"九.五"重点医学科研课题 ( No.96Z0 54 )
关键词
围手术期
肝叶切除
血小板膜
冠心病
perioperative period
coronary heart diseases
hepatectomy
platelet membrane glycoprotein
