4Chu C J,Keeffe E B,Han S.H,et al.Prevalence of HBV precore/core promoter variants in the United States[J].Hepatology,2003,38(3):619～628.
5Miykawa Y,Okamoto H,Mayumi M.The molecular basis of hepatitis B e antigen (HBeAg) negative infection[J].Viral Hepatitis,1997,4(1):1～8.
6Buckwold VE,Xu zhichang,Chen Min,et al.Effects of a naturally occurring mutation in the Hepatitis B virus basal core promoter on precore gene expression and Viral replication[J].Viral,1996,70(9):5 845～5 851.
7Gemer P,Lausch E,Friedt M,et al. Epatitis B virus core Promoter mutations in children with multiple anti-HBe HBeAg reactivations result in enhanced promoter activity [J] .JMed Virol, 1999,59:415.
8Scaglionipp, Melegarim, Wands JR. Biologic properties of hepatitis B viral genomes with multations in the precore premoter and precore open reading frame [J]. Virology, 1997,233:374.
9Gunthers, Piwon N, Will H. Wild-type levels of pregen in RNA and replication but reduced pre-CRNA and e-antigen synthesis of hepatitis B virus with C(1653)→T,A(1762)→Tand G(1764)→A mutations in the core promoter [J] .JGert Vird, 1998,79:375.
10NishizonoA, KohnoK, Takita-SonodaY, et al Sequential analyses of themurations in the core up stream and precore regions of hepatitis B virus genome in anti-HBe positive-carriers developing acute exacerbation [ J ]. JMed Virol, 1997,53(3) :266.
