摘要
目的 研究侵袭性与非侵袭性泌乳素 (PRL)腺瘤细胞增殖活性的差异。方法 检测 2 6例泌乳素腺瘤中细胞核增殖抗原 (PCNA)表达 ;用流式细胞仪 (FCM )检测相应腺瘤中S期细胞比例 ,比较侵袭性泌乳素腺瘤与非侵袭性泌乳素腺瘤PCNA表达与S期细胞比例的差异。结果 侵袭性PRL腺瘤中PCNA表达的阳性指数为 76 7±1 1 1 8;非侵袭性腺瘤中PCNA表达的阳性指数为 37 1± 1 0 33;两组比较 ,差别具有显著性 (P <0 0 5) ;侵袭性PRL腺瘤S期细胞比例为 1 3 57%± 2 1 6 % ;非侵袭性PRL腺瘤为 8 97%± 2 0 7% ,两组比较差别具有显著性 (P <0 0 5)。结论 PCNA表达与S期细胞比例的检测结果是一致的 ,侵袭性与非侵袭性PRL腺瘤相比 ,细胞增殖能力较强 。
Objective To evaluate the difference in proliferation between invasive and non invasive prolactinomas. Methods The proliferating cell nuclear antigen(PCNA) expression and the ratio of S phase cells were detected in 26 patients with prolactinoma, and the difference between invasive and non-invasive prolactinomas were compared. Results The PCNA positive index detected in invasive prolactinoma (76.7±11.18%) was significantly higher than non invasive tumor (37.1±10.33%, P<0.05 ). The ratio of S phase cells in invasive prolacinoma (13.57±2.16%) was also significantly higher than non invasive tumors(8.97±2.07%). Conclusions The proliferative ability of invasive prolactinomas was increased compared with non-proliferative adenomas.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2002年第2期113-114,共2页
Chinese Journal of Nervous and Mental Diseases
