摘要
目的 探讨 10号染色体有缺失且与tensin同源的磷酸酯酶基因 (PTEN )在乳腺癌组织中的表达及其意义。方法 采用免疫组织化学S P法 ,检测 71例乳腺癌组织中PTEN蛋白的表达水平。结果 正常乳腺组织中PTEN呈高表达 ;有腋淋巴结转移的乳腺癌组织中PTEN高表达率为 3 7.8% ,明显低于无腋淋巴结转移者 (P <0 .0 5 ) ;ER阳性者PTEN高表达率明显低于ER阴性者 (P <0 .0 5 ) ;出现远处转移的乳腺癌组织其PTEN高表达率也显著降低 (P <0 .0 1)。PTEN表达水平与患者年龄、肿瘤大小、组织学分级及临床分期无关 ,但随组织学分级和临床分期的增高 ,PTEN高表达率呈下降趋势。结论 PTEN表达异常与乳腺癌发生发展密切相关 ,PTEN低表达的乳腺癌恶性程度高。
Objective To study the expression and biological significance of PTEN in breast cancer.Motheds Expression of PTEN in 71 case of breast cancer were detected by immunohistochemistry S P method.Results High expression of PTEN was found in all normal breast tissues.In axillary lymph node metastasis groups,PTEN was expressed with a high positive rate of 37.8% ,it was lower than in the group without axillary lymph node metastasis( P <0.05).High expression rate of PTEN was significantly higher in estrogen receptor positive groups than in estrogen receptor negative groups( P <0.05).In distant metastasis groups,high expression rate of PTEN was markedly declined( P <0.01).Expression of PTEN was not related to age,tumor size,histologic grade,and clinical stage.However,as increasing of histologic grade and clinical stage,the high PTEN expression was declined.Conclusion Abnormal expression of PTEN is associatated with the development of breast cancer.
出处
《实用癌症杂志》
2002年第1期37-39,共3页
The Practical Journal of Cancer
关键词
基因表达
乳腺癌
抑癌基因
PTEN
Phosphatase and tensin homolog deleted on chromosome ten
Gene expression
Breast carcinoma
