摘要
目的 探讨天然维生素 E对果蝇寿命的影响和对老龄大鼠抗氧化作用。 方法 按卫生部《保健食品功能学评价程序和检验方法》中延缓衰老作用检验方法进行测定。果蝇喂饲剂量为 0 .0 1%、0 .0 3 %、0 .0 9%、0 .2 7% ;老龄大鼠灌胃剂量为 0 .0 8、0 .16、0 .4 8g/ kg· bw。 结果 喂饲 0 .0 3 %、0 .0 9%浓度的天然维生素 E,雌雄果蝇平均寿命和平均最高寿命均显著延长。经口给予老龄大鼠天然维生素 E0 .16g/ kg、0 .4 8g/ kg血清中过氧化脂质降解产物 -丙二醛 ( MDA)含量明显降低 ,超氧化物歧化酶 ( SOD)活力显著增强。 结论 提示天然维生素 E可以延缓机体衰老过程 。
Objective To investigate effects of natural vitamin E on life span in drosophila melanogaster and on antioxidation in rats. Methods According to anti-aging test methods in 'Health Food Functional Assessment Procedure and Test Methods' by Health Ministry, the doses fed to drosophila melanogasters were 0.01%, 0.03%, 0.09%, 0.27%, and for old rats were 0.08, 0.16, 0.48g/kg·bw. Result The average life span and average maximum life span of both male and female drosophila melanogasters fed on media containing 0.03%, 0.09% natural vitamin E were significantly longer than those fed on pure maize powder media. The serum content of lipid peroxides degradation product, malondialdehyde(MDA), in rats dosed with 0.16g/kg, 0.48g/kg natural vitamin E were significantly lower than that in controlled ones, and the serum total superoxide dismutase(SOD) activity in both groups were significantly higher compared with controls. Conclusion The natural vitamin E could delay body's aging , and it had anti-aging effect.
出处
《实用预防医学》
CAS
2002年第1期32-33,共2页
Practical Preventive Medicine
关键词
天然维生素E
延缓衰老
抗氧化
果蝇寿命
实验
药理
Natural vitamin E
Anti-aging
Antioxidation
Life span of drosophila melanogasters
