摘要
目的 评价高剂量率近距离放射治疗 (放疗 )原发性阴道癌的效果 ,并与传统腔内镭疗进行比较。方法 对 1989年 1月～ 1999年 12月期间接受了高剂量率近距离放疗的原发性阴道癌患者 5 1例的临床资料进行回顾性分析。按国际妇产科联盟 (FIGO)临床分期标准进行分期 ,Ⅰ期 10例 ,Ⅱ期 13例 ,Ⅲ期 2 3例 ,Ⅳ期 5例。 5 1例患者均接受了以放疗为主的治疗。体外照射予直线加速器产生的 6MV或 8MVX线盆腔前后野垂直轮流照射 ,照射剂量为盆腔正中平面 40～ 5 0Gy ;有 3例患者辅助双侧腹股沟野照射 ,照射剂量 45～ 5 0Gy ;2例辅助外阴野照射 ,照射剂量 30～ 40Gy。腔内治疗应用WD HDR18治疗机 ,11例在阴道盒治疗时部分应用了Buchler治疗机。治疗时 ,根据肿瘤部位、大小、厚度等情况分别或联合应用阴道盒、阴道塞子、宫腔管或组织间插植针进行治疗。结果 患者的总 5年生存率为 5 8 8% ,其中Ⅰ期 80 0 % ,Ⅱ期 76 9% ,Ⅲ期 6 5 2 % ,Ⅳ期 5例中 0例。各期 5年生存率均高于本院报道的传统的以腔内镭疗为主治疗原发性阴道癌的疗效。结论 高剂量率近距离放疗单独应用或与体外照射等联合应用治疗原发性阴道癌可取得不低于传统腔内镭疗的疗效 ,而且并发症发生率无明显提高。
Objective To evaluate the efficacy of radiation therapy on primary vaginal cancer with high dose rate brachytherapy alone or in combination with external radiation Methods Fifty one cases with primary vaginal cancer who were treated with high dose rate brachytherapy alone or in combination with the external radiation in Cancer Hospital, Chinese Academy of Medical Sciences from 1989 to 1999 were retrospectively studied,including stage Ⅰ 10 cases,stage Ⅱ 13 cases,stage Ⅲ 23 cases and stage Ⅳ 5 cases WD HDR18 after loading equipment was used in the brachytherapy and 6 or 8 MV linear accelerator was used in the external radiation Results The overall 5 year survival rate with WD HDR18 was 58 8%, with 80 0% for stage Ⅰ,76 9% for stage Ⅱ,65 2% for stage Ⅲ,and 0 0% for stage Ⅳ The comparison of treatments with WD HDR18 and radium therapy showed the 5 year survival rates of the cases of each stage treated with WD HDR18 were higher Conclusion Treatment results obtained with high dose rate brachytherapy are at least similar to traditional radium therapy for primary vaginal cancer
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2002年第2期94-96,共3页
Chinese Journal of Obstetrics and Gynecology
