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帕罗西汀与氟西汀对脑卒中后抑郁总体康复影响的对照研究 被引量:12

A controlled trial comparing the total rehabilitation of paroxetine and fluoxtine in the treatment of poststroke depression
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摘要 目的 比较帕罗西汀与氟西汀 (百忧解 )对脑卒中后抑郁总体康复的影响。方法 将符合入组标准的脑卒中后抑郁患者随机分为帕罗西汀组 ,氟西汀组 ,用汉密顿抑郁量表 ( HAMD) ,汉密顿焦虑量表 ( HAMD) ,副反应量表 ( TESS)和改良爱丁堡与斯堪的维亚评分 ( SSS)进行评估。结果 帕罗西汀组与氟西汀组治疗前与治疗后第 4 ,8周 SSS评分均有显著差异 ,帕罗西汀组与氟西汀组之间无差异。治疗后第 2周帕罗西汀组与氟西汀组 HAMA评分有显著差异。结论 帕罗西汀与氟西汀均能有效地治疗脑卒中后抑郁 ,加快病人总体康复 。 Objective To study the efficacy of the total rehabilitation of paroxetine and fluoxtine in the treatment of poststroke depression.Method Patients with diagnosis of poststroke depression and fulfilling the admission criteria to the study were randomly assigned to two groups that were treated with paroxetine and fluoxtine.The therapeutic response were evaluated with HAMD,HAMA,TESS and SSS.Results There were significant difference with SSS between before and post the treatment of both paroxetine and fluoxtine.The effect of paroxetine were superior to that of fluoxtine with significant difference as measured with the HAMA in the 2nd week.Conclusion Both paroxetine and fluoxtine accelerated the total rehabilitation of poststroke depression.Paroxetine can ameliorate anxiety more efficiently and the treatment obedience were superior to that of fluoxtine.
出处 《健康心理学杂志》 2001年第6期461-463,共3页 Health Psychology Journal
关键词 脑卒中后抑郁 帕罗西汀 氟西汀 康复 Paroxetine Fluoxtine Poststroke
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参考文献6

  • 1张通,孟家眉,项曼君.脑卒中后抑郁症的前瞻性研究[J].中华精神科杂志,1996,29(2):73-76. 被引量:174
  • 2中华医学会.脑血管病诊断和分类诊断要点,神经功能缺损程度的评分标准[J].中华神经科杂志,1996,29(5):376-376.
  • 3Paul W.Depression:a psychobilogical synthesis.London:Awiley-Intersci ence Publication,1985,48.
  • 4Fulop G et al.Am J Psychiatry,1987,144:878.
  • 5邢诒刚,陶恩祥.氟西汀对脑梗死后伴抑郁症状患者总体康复的影响[J].中国神经精神疾病杂志,1999,25(4):231-232. 被引量:53
  • 6张淑敏 马璟 程继明.帕罗西汀治疗脑卒中后抑郁症的临床研究[J].中国神经精神疾病杂志,2000,26(6):375-375.

二级参考文献2

  • 1孟家眉,中华神经精神科杂志,1988年,21卷,57页
  • 2中华医学会,中华神经科杂志,1996年,29卷,5期,376页

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