摘要
目的 :探讨急性心肌梗死 (AMI)后早期应用卡托普利联合美托洛尔与单用卡托普利对左室重构的不同影响。方法 :6 2例AMI患者随机分成治疗组 (卡托普利联合美托洛尔 ) 30例和对照组 (单用卡托普利 ) 32例 ,采用彩色多普勒心动超声仪 ,分别于发病后 1,2 ,3wk连续测量并计算左室形态、构型等多项指标。结果 :2组AMI患者中 ,对照组左室形态和构型变化比治疗组显著加重 (P <0 0 5 ) ,且从 1wk到 3wk呈进行性加重 ,wk 3最明显。结论 :在AMI早期 。
AIM: To study different effect of left ventricular remodeling (LVR) after acute myocardial infarction (AMI) in early stage using captopril in combination with metoprolol and single captopril. METHODS: The indexes of left ventricular shape, geometry were measured in 62 patients of treatment group (captopril and metoprolol) 30 and contrast group (captopril) 32 with AMI at 1, 2 and 3 wk after the attack using echocardiography. RESULTS: The changes of left ventricular shape and geometry in contrast group were more obvious than treatment group, it was progressively worse from 1 wk to 3 wk after attack with the peak at wk 3 ( P <0 05). CONCLUSION: The captopril in combination with metoprolol in inhibitory action of LVR was more effective than single captopril after AMI in early stage.
出处
《中国临床药学杂志》
CAS
2002年第1期7-9,共3页
Chinese Journal of Clinical Pharmacy
