摘要
目的 了解脑梗死患者血清IL - 1β、sICAM - 1含量在急性期和恢复期的变化及意义。 方法 运用酶联免疫吸附法 (ELISA)测定血清中IL - 1β、sICAM - 1含量。 结果 急性期、恢复期脑梗死患者血清IL - 1β、sICAM - 1水平均较对照组显著增高 (P <0 .0 1,P <0 .0 1;P <0 .0 1,P <0 .0 5 ) ,急性期又较恢复期明显增高 (P <0 .0 1,P <0 .0 5 ) ,两者增高程度与梗死灶大小密切相关 ;且急性期脑梗死患者sICAM - 1的水平与IL - 1β的水平呈正相关 (r =0 .6 9,P <0 .0 0 1) ,恢复期脑梗死患者的sICAM - 1与IL - 1β呈正相关 (r =0 .48,P <0 .0 1)。结论 IL - 1β、ICAM - 1可能参与了脑梗死早期的炎症反应及再灌注损伤 ,临床脑梗死I CAM - 1表达上调可能与炎性细胞因子IL -
Objective To observe the changes of serum levels of interleukin-1β (IL-1β) and soluble intercellular adhesion molecule-1(sICAM-1) between acute phase and recovery phase in patients with cerebral infarction.Methods Serum levels of IL-1β and sICAM-1 were measured by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-1β and sICAM-1 in patients with cerebral infarction of acute phase and recovery phase increased remarkably compared with control group( P < 0.01 , P < 0.01 ; P < 0.01 , P < 0.05 ),the levels in patients of acute phase also increased remarkably compared with recovery phase( P < 0.01 , P < 0.05 ). There was a positive correlation between the increased degree and different infarct volumes. There was a positive correlation between sICAM-1 and IL-1β in patients of acute or recovery phase ( r = 0.69 , P < 0.001 ; r = 0.48 , P < 0.01 ).Conclusion IL-1β and ICAM-1 may play an important role in the inflammatory reaction in early cerebral infarction and in the damage after reperfusion; The upregulated expression of ICAM-1 during cerebral ischemia in human probably correlated with inflammatory cytokine IL-1β.
出处
《卒中与神经疾病》
2002年第1期26-28,共3页
Stroke and Nervous Diseases
关键词
脑梗死
白介素1Β
细胞间粘附分子1
Cerebral infarction Interleukin-1β Soluble intercellular adhesion molecule-1
