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Alzheimer病的免疫学研究进展 被引量：3

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摘要 Alzheimer 病(AD)除了具有大脑皮质萎缩、神经细胞缺失、神经纤维缠结、炎性斑(SP)和脑血管β-淀粉样蛋白(Aβ)沉积的病理特征以外,还伴随着一个缓慢的炎性病理改变过程[1].随着分子免疫学和分子病理学技术的飞速发展,在AD患者脑内发现存在大量与炎症反应有关的免疫分子.其中关于白细胞介素(IL)、趋化因子、转化生长因子(TGF)以及补体等在AD免疫炎症反应中作用的研究较为深入,并取得了许多新的进展.为阐明AD的发病机制,澄清免疫学变化在AD慢性炎症过程中的作用极为重要.
作者 王琳 王文昭 王德生
机构地区 哈尔滨医科大学第一临床学院神经内科 上海第二军医大学长征医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2002年第1期62-64,共3页 Journal of Apoplexy and Nervous Diseases
关键词 ALZHEIMER病 免疫学 研究进展 IL 趋化因子 补体
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献15

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同被引文献27

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二级引证文献25

中风与神经疾病杂志
2002年 第1期

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