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对幽门螺杆菌有效中西药物筛选的实验研究 被引量:42

Experimental Study of Screening for Effective Chinese and Western Medicine to Helicobacter Pylori
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摘要 本研究经药敏试验从20种清热解毒中药中筛选出丹皮、乌梅、大黄、黄柏、三七、丹参、白芍、黄连8种对幽门螺杆菌有效的中药,抑菌直径6.88mm±0.12mm~9.25mm±0.42mm,上述药物与丹参、人参、"胃忧愈"或三种药物按排列组合方法进行药敏试验,结果与"胃忧愈"及:三种药物联合抑菌作用增强(8.13mm±1.06mm~13.62mm±0.14mm,P<0.01或P<0.05)达到中度敏感。14种抗生素的药敏试验显示为中度或高度敏感,每种抗生素与De-Nol和/或甲硝唑联合作用明显增加,这可能与其作用方式不同而产生协同作用有关。 In this study, eight effective Chinese medicinal herbs for helicobacter pylori were screening from 20 antipyretic and antidote drugs according to medical sensitive test.They were paeona suffruticosa,tructus mume,radix rhei ,phellodendron chinens,panax notoginseng,salvia miltiorrhiza ,radix paeonae alba, coptis chinense , whose bacteriostatic diameter were 6. 88± 0.12 ̄9. 25 ± 0. 42 mm. Every drugs taking of combine radix ginseng,salvia miltiorrhaza or'WEI YOU YU'or mixing any three of above eight chinese herbs according to permutative combination were carried on medical sensitive test. Sensitivity for combining' WEI YOU YU' with every drug or mixing any three of it was increased(8. 13±1. 06~13.62±0. 14 mm,P<0. 01 or P<0.05), and achieved to medium sensitivity. The medical sensitive test of 14 antibiotic showed medium or high sensitivity. When using of antibiotic with De-Nol and/or metronidazole remarkable increasing bacteriostasis was observed duing to different active way of antibiotic and cooperating effect.
出处 《胃肠病学和肝病学杂志》 CAS 1995年第4期267-270,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 幽门螺杆菌 中药 抗生素 药敏试验 helicobacter pylori Chinese medicinal herbs antibiotic medical sensitive test
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