摘要
以 6 -甲基 - 2 - (4 -甲基苯基 ) -咪唑并 [1,2 - a]吡啶为起始原料 ,经缩合、氯化、脱氯、成盐等步反应制得酒石酸唑吡坦 ,总收率为 35 .7%。该合成路线具有原料廉价易得、操作简便、易于工业化生产等优点。
Objective: To prepare compound Zolpidem Tartrate. Methods: The compound was synthesised from 6-methyl-2(4-methylphenyl) imidazo pyridine via condensation, chlorination, dechlorination, and formation of tartrate salt. Results: The total yield was 35.7%. Conclusion: The result showed that it was a cheap, simple and easy method.
出处
《天津药学》
2002年第1期69-70,共2页
Tianjin Pharmacy
