摘要
目的:探讨急性心肌梗死和急性脑梗死时黏附分子、血小板第4因子(PF4)和D-二聚体(DD)的临床意义。方法:分别对30例急性心肌梗死(AMI组)、23例急性脑梗死(ACI组)患者外周血的可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞轴附分于-1(sVCAM-1)、D二聚体、血小板第4因子进行检测并与健康对照组进行比较。结果:AMI组及ACI组在发病24h内及发病1周时血清sICAM-1、sVCAM-1、DD、PF4值均显著高于对照组(均P<0.01),AMI组在发病1周时以上各值均高于ACI组(P<0.01或P<0.05)。结论:在心肌梗死和脑梗死发病初期及发病1周时,sICAM-1、sVCAM-1、DD、PF4相互作用共同参与急性血栓形成过程,为早期使用抗黏附分子抗体及药物治疗提供临床实验依据。
Objective: To explore the clinical significances of adhesive molecule and its relative factors in patients with acute myo-cardial infarction (AMI) or acute cerebral infarction (ACI). Methods: The scrum solvable intercellular adhesion molecule-1 (sICAM-1 ), solvable vascular cell adhesion molecule-1 (sVCAM-1), D-dimer (D-D) and platelet factor 4 (PF4) were measured in 30 patients with AMI, 23 patients with AC I and 30 healthy controls. Results: The levels of serum sICAM-1 , sVCAM-1 , D-D and PF4 from 24 hours to one week in AMI and ACI groups were significantly higher than those in control group (P<0.001). In one week, the levels in AMI group were higher than those in ACI group (P<0.01 or 0.05). Conclusion: The levels of serum sICAM-1 , sVCAM-1 , D-D and PF4 in AMI and ACI continuously increase from 24 hours to one week, which takes part in acute thrombotic process. The use of anti-adhesion molecular antibody and drug may prevent or relief the process.
出处
《天津医药》
CAS
北大核心
2002年第3期137-139,共3页
Tianjin Medical Journal
关键词
心肌梗塞
脑梗塞
胸间黏附分子1
纤维蛋白纤维蛋白原降解物
血小板因子4
myocardial infarction cerebral infarction intercellular adhesion molecule-1 fibrin fibrinpgcn degrada-tion products platelet factor 4
