摘要
目的 :探讨血管内皮生长因子 (VEGF)的表达与喉鳞状细胞癌的临床病理关系。方法 :采用SP免疫组织化学染色技术 ,评价 87例喉鳞癌患者的肿瘤组织中VEGF的表达和微血管计数 (MVC)。资料分析采用SAS软件。结果 :在喉鳞状细胞癌中 ,VEGF的免疫反应主要发生于肿瘤细胞的胞浆内 ,其阳性率为 77.0 %。肿瘤侵犯范围越广 ,VEGF的表达越强 ,肿瘤侵犯范围越小 ,VEGF的表达越弱 (P <0 .0 5 ) ;肿瘤分化越差 ,VEGF的表达越强 ,肿瘤分化越好 ,VEGF的表达越弱 (P <0 .0 5 ) ;VEGF的表达越强 ,MVC越多 ,二者呈明显的正相关(P <0 .0 1) ,且肿瘤组织中的平均MVC明显高于切缘组织中的平均MVC(P <0 .0 1)。结论 :在喉鳞状细胞癌中 ,VEGF的表达与肿瘤的临床分期和分化明显相关 ,与MVC存在着明显的正相关 。
Objective:To approach the relation between vascular endothelial growth factor(VEGF)expression and clinical pathological character in laryngeal squamous cell carcinoma.Method:Immunohistochemical staining(SP) was used to evaluated the expression of VEGF and microvessel count(MVC) in tumor tissues from 87 patients with laryngeal squamous cell carcinoma.Result:VEGF immune response was mainly localized to the tumor cell cytoplasm,positive rate was 77%.In laryngeal squamous cell carcinoma,the wider the tumor invaded,the stronger VEGF expressed,the fewer the tumor invaded,the weaker VEGF expressed (P< 0.05 );The lower the tumor differentiated,the stronger VEGF expressed,the higher the tumor differentiated,the weaker VEGF expressed(P< 0.05 );The stronger VEGF expressed,the more MVC were(P< 0.01 );The mean MVC in tumor tissues was obviously higher than that in surgical margin tissues(P< 0.01 ).Conclusion:In laryngeal squamous cell carcinoma,the expression of VEGF was markedly correlated with tumor stage and differentiation,was positively correlated with MVC.As a result,VEGF may have an important role in the progression of laryngeal squamous cell carcinoma.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2002年第3期111-113,W001,共4页
Journal of Clinical Otorhinolaryngology
